Nineteen people were feared dead and 45 injured after an attack by a knife-wielding man at a facility for the disabled in Japan early on Tuesday, national broadcaster NHK reported.

Police in Sagamihara, Kanagawa Prefecture, about 25 miles southwest of Tokyo, have arrested Satoshi Uematsu, a 26-year old former employee at the facility, Japanese media reported.

They said staff called police at 2.30 a.m. local time with reports of a man armed with a knife on the grounds of the Tsukui Yamayuri-En facility.

The 7.6 acres facility, established by the local government and nestled on the wooded bank of the Sagami River, cares for people with a wide range of disabilities, NHK said, quoting an unidentified employee.

Media reports said the man, wearing a black T-shirt, did not have a knife when he turned himself in at a nearby police station. Police said they were still investigating possible motives.

Asahi Shimbun reported that the suspect was quoted by police as saying: "I want to get rid of the disabled from this world."

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Fifteen people were confirmed dead while four were in cardiac arrest, the media reports said. The wounded were taken to at least six hospitals in the western Tokyo area.

Twenty-nine emergency squads responded to the attack, Kyodo reported.

A man identified as the father of a patient in the facility told NHK he learned about the attack on the radio and had received no information from the center.

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"I'm very worried but they won't let me in," he said, standing just outside a cordon of yellow crime-scene tape.

Kyodo, citing the facility's website, said the center had a maximum capacity of 150 people.

Such mass killings are rare in Japan. Eight children were stabbed to death at their school by a former janitor in 2001.

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