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Doña Lety is now the alleged leader of the cartel that dominates Cancun and Playa del Carmen.
She's successfully replaced the notoriously violent Zetas' special forces that used to control the area and even managed to bring together ex-members of the Sinaloa Cartel, Gulf Cartel and Zeta Cartel, in addition to being known for recruiting ex-convicts.
Leticia Rodríguez Lara, who's known as La 40, is the leader of a Mexican cartel that's become so powerful she single-handedly caused Los Zetas, Gulf Cartel and Los Pelones to form an alliance in an attempt to take her down.
Her rise to power is now compared to that of other women leaders of more established cartel groups in Mexico, such as Clara Elena Laborín Archuelta, La Señora, who's believed to be married to Héctor Beltrán Leyva and the current leader of the cartel named after her infamous husband's brother.
La Señora was arrested on September 12 in Hermosillo, Sonora.
Authorities claim she was responsible for inciting the wave of violence that has taken over the once popular tourist destination of Acapulco.
It is believed La Señora was fighting for power of the Beltrán Leyva Cartel from Enedina Beltrán Leyva, the sister of the cartel's founder.
According to a report released by the DEA, Enedina, who goes by the alias La Narcomami, is the new leader of the Beltrán Leyva Cartel after her son, Fernando Sánchez Arellano, was arrested in June 2014.
Sandra Ávila Beltrán, La Reina del Pacífico (The Queen of the Pacific), is yet another of the many women believed to lead drug trafficking operations in Mexico.
La Reina del Pacífico is allegedly responsible for trafficking large shipments of cocaine from Colobia to Mexico in clandestine ships.
According to Mexico's top prosecutor, La La Reina del Pacífico currently acts as the link between Colombian and Mexican drug lords.
Ávila Beltrán is now free after facing money laundering charges both in Mexico and the United States.
Finally, despite publicly denying the allegations, Claudia Ochoa Félix is believed to be the leader of Los Ántrax, the armed wing of the Ismael El Mayo Zambada Cartel.
La Emperatriz Ántrax, as she's known, has an active presence on social media where she's become famous for posing with machine guns and massive stacks of cash.